MAPK11 and metastatic malignant neoplasm in the lymph nodes: Additionally, Liu et al. disclosed the remarkably downregulated TRIM67 expression in CRC tissues, and TRIM67 expression was related to clinical stage, invasion, tumor size, lymph node metastasis, and staging; besides, TRIM67 played an inhibitory role in the proliferation, migration and invasion of CRC cells by mediating MAPK11 [33].