Finally, as KRT14+ cell cycle activation occurs after many other types of urothelial injury, such as spinal cord injury (Kullmann et al., 2017), radiation cystitis (Jaal & Dorr, 2010), and urinary tract infections (Colopy et al., 2014; Mysorekar et al., 2009), people with mutations or variants in FGF7/FGF10/FGFR2IIIb or ERK1/2 families could have increased risks for abnormal urothelial regeneration after these insults. This evidence concerns the gene FGF7 and urinary tract infection.