Also in experiments with myocardial ischemic in rodents, VNS restored mitochondrial dynamics through regulation of Drp1, Fis-1, OPA1 and Mfn1/2; enhanced ATP content and mitochondrial membrane potential; reduced MPTP opening, and improved mitochondrial ultrastructure and size, suggesting that VNS has therapeutic roles in reducing myocardial infarction, ameliorating cardiomyocyte apoptosis, and moderating cardiac dysfunction (Xue et al., 2017). The gene discussed is MFN1; the disease is myocardial infarction.