Interestingly, Cp keratinocytes co-cultured with ANp fibroblasts displayed a moderate reduction of β-catenin, E-cadherin, involucrin and 14–3-3 sigma expression in concomitance with a slight increase of vimentin (Fig. 2C, D, compare Cp + HF-ANp vs Cp + HF-Cp and Cp). This evidence concerns the gene NPPA and hydrops fetalis.