In a hepatocellular carcinoma murine model, the hypoxic environment in the tumor caused hypoxia-inducible factor-1 (HIF-1) to activate CXCL26 transcription in cancer cells, thereby recruiting MDSCs expressing the CXCL26 receptor CX3CR1 into the primary tumor site [40]. The gene discussed is HIF1A; the disease is neoplasm.