In patients with acute promyelocytic leukemia (APL), tumor-activated intrinsic lymphocytes (ILC2) secrete IL-13 to induce M-MDSC production and support tumor growth, whereas all-trans retinoic acid (ATRA) treatment reverses the ILC2-induced increase in MDSCs [110]. The gene discussed is IL13; the disease is acute promyelocytic leukemia.