Another study showed that blockade of IFN receptor (IFNAR) signaling using IFNAR-deficient mice or anti-IFNAR monoclonal antibodies (mAbs) abrogated NET formation with significantly fewer NET-forming neutrophils detected in the lung lesions of TB-susceptible mice, revealing an important role of type I IFN in inducing NET formation [28]. The gene discussed is IFNAR1; the disease is tuberculosis.