DNAJA3 and colorectal cancer: Similarly, hTid-1 expression levels are found to play a key role in the progression of colorectal cancers as explained in brief in Fig. 5D. Sporadic and inherited colon tumors both arise from precancerous polyps or adenomas sequentially [100], via a chain of genetic alterations in the evolutionarily conserved tumor suppressor genes and oncogenes, each associated with well-defined morphological changes [101].