ERBB2 and breast cancer: Similarly, an important protein in Breast Cancer signaling, ErbB2 has also been found to be regulated by hTid-1 as pointed out in Fig. 4D. Carboxyl terminus of heat shock cognate 70 interacting protein (CHIP), has also been found to efficiently downregulate ErbB2 in vitro, quite similar to h-hTid-1.