When the expression and correlation between CHIP, hTid-1 and ErbB2 were analyzed using immunohistochemistry (IHC) and immunoblotting assays in 183 breast cancer histology sections, which included 30 fresh tissue specimens, it was found that hTid-1 and CHIP positively correlate with each other and inversely with ErbB2 and that hTid-1 and CHIP act in synergy to degrade ErbB2 in vitro [92]. Here, STUB1 is linked to breast cancer.