It has been observed that hTid-1 is either reduced or absent in clinical samples from oral cancer patients [27, 28], while in Head and Neck Squamous Cell Carcinomas, hTid-1 has been found to negatively regulate Galectin-7 (which plays an important role in disease progression), by its ubiquitination and subsequent proteasomal degradation [29]. The gene discussed is DNAJA3; the disease is lip and oral cavity carcinoma.