DNAJA3 and breast cancer: As shown in Fig. 5C, in breast cancer studies, hTid-1 has been found to regulate the Erb-B2 Receptor Tyrosine Kinase 2, commonly called the ErbB2/HER2 receptor, by acting as an E3 ligase for the protein, thereby facilitating attachment of poly-ubiquitin chains, leading to subsequent proteasomal degradation of the receptor [46].