ERBB2 and carcinoma: It is observed that in ErbB2-overexpressing carcinoma cells, the co-chaperone activity and regulation of Hsp70 by hTid-1 plays an important role in preventing the uncontrolled proliferation of cells by actively decreasing the expression of ErbB2, thereby resulting in the suppression of the ErbB2-dependent cancerous signaling and tumor progression [46].