hTid-1 has been found to play the role of a tumor suppressor in these cases as shown in Fig. 5A. Chen et al. [27] analyzed the protein levels of hTid-1 in the biopsies of 47 HNSCC and NCMT (non-cancerous matched tissues) pairs by Immunohistochemistry studies, and the hTid-1 expression was found to be inversely correlated with tumor differentiation. The gene discussed is DNAJA3; the disease is head and neck squamous cell carcinoma.