While the focus of the earliest research on hTid-1 was on understanding the interactions of hTid-1 with different proteins in the cell, and its role in cellular signaling pathways, it was only in the past decade that a lot of focus shifted to investigating the role of hTid-1 in the context of different diseases such as cancers, cardiomyopathies, and neurodegenerative diseases. Here, DNAJA3 is linked to neurodegenerative disease.