TP53 and cancer: It was also found that when hTid-1 was overexpressed in mutant p53-expressing cancer cells such as T47D (p53 mt−L194F), SK-BR-3 (p53 mt−R175H), BT474 (p53 mt−E285K) and the glioma cell line, U373 (p53 mt−R273H), which lacked transcriptional activity, it restored the localization into mitochondria and the pro-apoptotic activities of mutant p53 [26].