The Tid50/Tid48 cytosolic splice variants of hTid-1 and the Adenomatous Polyposis Coli (APC) tumor suppressor associate with each other in different tissue samples such as colorectal cancer cells, normal colon epithelium, and mouse NIH3T3 fibroblasts, and it has been found that the Armadillo domain (ARM) containing N-terminal region of APC is sufficient for interaction with hTid-1 molecules [68]. Here, APC is linked to colorectal cancer.