In the present study, we analyzed the expression of M0RGs using single-cell sequencing data, and the results revealed that two M0RGs, ATIC and OLA1, were expressed more abundantly in specific subgroups of T cells with signature markers, such as the CD4-CTLA4, CD8-LAYN, CD8-GZMK, and CD4-CXCL13 bundles of HCC tissues. The gene discussed is ATIC; the disease is hepatocellular carcinoma.