Interestingly, although RBP ESRP1/2 could bind with several circRNAs, such as circUHRF1 in HNSCC cells, ESRP1 enhanced the biogenesis of circUHRF1 via a direct association to regulate c-MYC signaling and HNSCC development [34], which was indicative of the interaction between RBPs and circRNAs in HNSCC’s pathogenesis. This evidence concerns the gene ESRP1 and head and neck squamous cell carcinoma.