Functional gene expression networks controlled by RBPs, such as ADAR1, DDX3, FXR1, and ESRP1/2 (epithelial splicing regulatory proteins 1/2), were closely associated with HNSCC cell’s migration and invasiveness, including cancer metastasis and poor prognosis [19], thereby serving as new promising targets for HNSCC’s treatment. The gene discussed is ESRP1; the disease is cancer.