Furthermore, circRNAs can regulate multiple cancer-related signaling pathways, such as the microRNA sponges during HNSCC’s pathogenesis, involving EGFR, Notch, mTOR (mammalian target of Rapamycin), and MAPK (mitogen-activated protein kinase) signaling pathways [11–14]. This evidence concerns the gene WNK2 and head and neck squamous cell carcinoma.