FZD7 and familial pancreatic carcinoma: It is currently believed that CSCs are more resistant to chemotherapy than normal tumor cells (Rao and Mohammed 2015; Valle et al. 2018); Our previous study also showed that FZD7 can synergize with Wnt7b to increase the proportion of PDAC CSCs and enhance drug resistance of pancreatic cancer cells (Zhang et al. 2021).