To investigate the role of FZD7 in pancreatic cancer, we investigated high level of FZD7 expression in PDAC tissue sample firstly, then demonstrated that high levels of FZD7 expression associated with earlier hepatic metastasis in PDAC patients, and high FZD7 expression can promote EMT and CSC amplification in vitro; we also confirmed the correlation between CSC and EMT, and the synergistic effect of FZD7 with TGF-β/SMAD3, so explained the mechanism of FZD7 high expression promoting hepatic metastasis. This evidence concerns the gene SMAD3 and familial pancreatic carcinoma.