It is currently believed that CSCs are more resistant to chemotherapy than normal tumor cells (Rao and Mohammed 2015; Valle et al. 2018); Our previous study also showed that FZD7 can synergize with Wnt7b to increase the proportion of PDAC CSCs and enhance drug resistance of pancreatic cancer cells (Zhang et al. 2021). Here, WNT7B is linked to familial pancreatic carcinoma.