Of the 102 genes, 28 in CP (23 upregulated and 5 downregulated) and 33 genes in PDAC-CP (1 upregulated and 32 downregulated; AKR1B1, − 2.76, Fig. 4D and KMT2C, − 2.67 Fig. 4E were tumour suppressors) were unique. The gene discussed is AKR1B1; the disease is neoplasm.