EIF2AK2 and viral infectious disease: The other upregulated genes were those involved in the host response to virus infection, such as PPP1R15A (protein phosphatase 1 regulatory subunit 15A), which codes for GADD34 complex, a host protein involved in the dephosphorylation of P-eIF2α (Eukaryotic Initiation Factor 2) by an interferon-induced double-stranded RNA-activated protein kinase (PKR) in a prominent cellular antiviral pathway [62, 86].