Finally, to test the tissue lineage context-specificity of ViroTreat predictions, we assessed the antiviral effect of the 8 ViroTreat predicted drugs for the GI context showing the strongest inhibition of SARS-CoV-2 infection in Caco-2, in lung adenocarcinoma cell line models (Calu-3 and ACE2-A549). The gene discussed is ACE2; the disease is lung adenocarcinoma.