As shown in Fig. 5c, although fasting blood glucose levels were similar between STOM Tg and WT mice, plasma insulin and insulin resistance measured by HOMA-IR experiments were significantly higher, and glucose tolerance measured by intraperitoneal glucose tolerance test (IPTGG) was more intolerable in HFD-fed STOM Tg than the control mice. The gene discussed is STOM; the disease is Insulin resistance.