As in our study, no single gene achieved genome-wide significance, but the gene with the smallest p value, FBN1, was pursued in a replication cohort similar to our approach and replicated together with the related gene FBN2. In the second study, Haller et al., analyzed exome sequence data of 391 severe AIS cases and 843 controls. This evidence concerns the gene FBN1 and androgen insensitivity syndrome.