Interestingly, two FAT3 variants rs139595720 (genotype A/G) and rs80293525 (genotype C/T) were enriched in scoliosis ≥ 40° (4.5% and 2.7% respectively) compared to < 40° (1.4% and 0.7%) and controls (1.2% and 0.8%). Here, FAT3 is linked to scoliosis.