In this study, we statistically analyzed the incidence of DDR pathway gene mutations in Chinese patients with HCC, and the results showed that about 20% of Chinese patients with HCC carried somatic or germline mutations of DDR pathway gene, among which the DDR genes with the highest mutation frequency were ATM and BRCA2, which is consistent with the previous conclusions of Lin J, et al.23. The gene discussed is BRCA2; the disease is hepatocellular carcinoma.