At 9h and 24h post-infection (multiplicity of infection; MOI 10), the distinctive cytopathic effect (round cells/detached cells), due to HSV-1 replication, was detected in the wild type cells expressing caspase-8 (CASP8+/+), while the CASP8-/- cells showed a less evident cytopathic effect. The gene discussed is CASP8; the disease is infection.