CASP8 and infection: We detected the lipidation of LC3 on THP-1 cells and CASP8+/+ by reporting an increased LC3-II/LC3-I ratio following R3630 infection in THP-1 and CASP8+/+ cells when compared to the HSV-1 infected cells or to the CASP8-/- cells (Fig. 6a lanes 3 vs 2 and 6 vs 5 and Fig 6b).