MRE11 and neoplasm: When nuclear and cytoplasmic expression of Mre11 was combined together, we observed that high nuclear/high cytoplasmic levels of Mre11 was associated with poor PFS (p = 0.016) (Fig. 1d) and poor OS (p = 0.007) (Fig. 1e) compared to tumours with low nuclear/low cytoplasmic Mre11 expression.