FGFR1 and lung cancer: In order to investigate the correlation between AKT activation and resistance to FGFR1 inhibition developed within lung cancer cells, we expanded the investigation to include a total of six lung-cancer cell lines, five of which (NCI-H1581, DMS114, LK2, NCI-H520 and NCI-H1703) showed elevated levels of FGFR1 protein and RNA expression compared with the control cell line HCC15 (Figs. 2a and S1a, b).