To further investigate the relationship between GCase function and LRRK2 kinase activity we used larger series of fibroblast lines, consisting of 4 control lines from healthy subjects and 6 LRRK2 G2019S fibroblasts from PD patients, which allowed us to better characterize the relationship between LRRK2 and GCase in the fibroblast model. Here, LRRK2 is linked to Parkinson disease.