LRRK2 and Parkinson disease: One possibility is that in both G2019S LRRK2 and GBA1-PD patients is more the misfolding and impaired trafficking that contribute to the PD pathogenesis, likely inducing ER stress, as recently shown by Stojkovska et al. (2022) in PD-midbrain neurons presenting α-synuclein aggregation and associated GCase-impaired proteostasis38.