Padua, 200883 and Wahdan-Alaswad 201685, used the TGF-β gene response signature (TBRS) to classify breast tumors as TGF-β gene responsive (TBRS+) and TGF-β gene unresponsive (TBRS-) breast tumor subtypes and found a higher correlation between TBRS+, and ER-83 and TNBC85 breast tumor subtypes. This evidence concerns the gene DNMT3A and breast neoplasm.