The variants in the functional domains, including the coiled-coil domain (p.K16M, p.L24F, and p.L35F), DNA-binding domain (p.R153W), ChAM (p.P405A), MRG15-binding domain (p.K628N and p.R663C), and WD40 domain (p.T1012I, p.E1018D, and p.T1099M), may disturb the function of PALB2, resulting in the cancer predisposition. Here, MORF4L1 is linked to cancer.