PET-CT results showed that in mice without Gal treatment, both TRAMP-C1(shHic1) and TRAMP-C1(shCtrl) cell-derived tumor tissues exhibited larger tumor volumes and higher 18F-FDG uptake in the subcutaneous flank region, which was further confirmed by quantitative analysis (Fig. 6b–e). The gene discussed is GAL; the disease is neoplasm.