Meanwhile, knockout of Hic1 accelerated tumor onset as shown in dCKO mice, which had higher pathological stage-high-grade prostatic intraepithelial neoplastic (PIN) lesions at 17 weeks of age (PIN III/IV vs. PIN II/III) and progressed into PRAD with a higher penetrance at 22–26 weeks old compared with Ctrl mice (12/19 vs. 3/18) (Fig. 1c, d). This evidence concerns the gene HIC1 and prostate intraepithelial neoplasia.