To investigate this possibility, HIC1-deleted PC3 and C4–2B PCa cells (herein referred to as PC3 Ctrl/ PC3 sgHIC1 or C4-2B Ctrl/ C4-2B sgHIC1) were generated using the CRISPR-Cas9 system (Supplemental Fig. S2a). The gene discussed is HIC1; the disease is posterior cortical atrophy.