Furthermore, we also illustrated a self-reinforcing feedback loop in the pathophysiological process of PCa, which was realized by that epithelium/TGF-β-fibroblasts/CXCL12-M2 macrophages/CXCL5 trajectory, and finally in turn to enhance the malignant phenotype of PCa epithelial cells by EMT. Here, CXCL12 is linked to posterior cortical atrophy.