CFB and viral infectious disease: A recent report also showed that the fusogenicity mediated by the S proteins of BA.2.12.1, BA.4 and BA.5 is significantly enhanced when compared to that of the original BA.1 lineage.30 However, compared with previously dominant variants, these Omicron sublineages showed reduced clinical pathogenicity, possibly through the effects of routine vaccination, which is expected to effectively attenuate disease severity, even though failing to prevent viral infection.31