PROS1 and infection: Particularly, S protein, the most important functional protein for viral entry and infection, contains 31–37 mutations, many of which are shared among these sublineages: G142D in N-terminal domain (NTD) and G339D, S371L/F, S373P, S375F, K417N, N440K, S477N, T478K, E484A, Q498R, N501Y and Y505H in receptor-binding domain (RBD), as well as D614G, H655Y, N679K and P681H in S1 subunit and N764K, D796Y, Q954H and N969K in S2 subunit.