PIK3CA and neoplasm: We identified that alterations in Vogelgram21 genes such as APC (c.1861dupA/p.Thr621fs, c.4245delT/p.Ser1415fs), FBXW7 (c.1634A>G/p.Tyr545Cys, c.1435C>T/p.Arg479*), KRAS (c.35G>T/p.Gly12Val, c.34G>T/p.Gly12Cys) and PIK3CA (c.1634A>G/p.Glu545Gly) and TP53 (c.916C>T/p.Arg306*) initiated the development of tumor as these mutations were found in the trunk of the phylogenetic tree.