We generated the NestinCre/+; p53f/f; Ptenf/+; R26tdTomato/+ tumour model in which Cre-mediated recombination results in the activation of the tdTomato reporter as well as the homozygous and heterozygous deletion of the two tumour suppressors, Tp53 and Pten, respectively, genes that are mutated/deleted in many GBM patients60. This evidence concerns the gene TP53 and glioblastoma.