In addition to HCC, IHC analysis of TMA showed significantly higher expression of ZCCHC4 in pancreatic cancer (PC), colon cancer (CC), and lung cancer (LC) tissues compared to that in their paired non-tumor tissues (Fig. 1f–h and Supplementary Fig. S1d–i). The gene discussed is ZCCHC4; the disease is familial pancreatic carcinoma.