Considering the GSEA analysis results and that platinum-based drug could form DNA adducts in cells, followed by inducing DDR and ultimately apoptosis27,28, we speculated that ZCCHC4 could modulate DDA-induced DDR in HCC cells which may contribute to ZCCHC4-potentiated chemoresistance. The gene discussed is ZCCHC4; the disease is hepatocellular carcinoma.