ZCCHC4 could promote the proliferation of HCC cells in vitro and in vivo, which is partially dependent on catalyzing rRNA methylation and promoting optimal global translation.21 However, the role of ZCCHC4 in regulating other aspects of cancer biology and pathology, the relationship between ZCCHC4 and cancer prognosis, and the feasibility of ZCCHC4 serving as cancer therapeutic target remain unknown. This evidence concerns the gene ZCCHC4 and cancer.