Parathyroid hormone (PTH) is a calcium-modulated hormone secreted by the parathyroid gland.13 PTH-related peptide (PTHrP), which includes two fragments, PTH (1–84) and PTH (1–34), binds parathyroid hormone 1 receptor (PTH1R) on osteoblast cell membranes and activates downstream signals to regulate bone metabolism.14 PTH induces the differentiation and formation of osteoblasts as the basis for the treatment of osteoporosis.15 On the other hand, PTH increases the number and vitality of osteoclasts and promotes bone resorption. Here, PTH1R is linked to osteoporosis.