ACE2 and viral infectious disease: Considering that the S protein is extensively decorated by glycans,30 it is not surprising that lectin receptors can promote viral infection through the nonspecific attachment to the glycan shield of SARS-CoV-2.31 For instance, the NTD of SARS-CoV-2 S1 subunit has a sialic acid-binding pocket that can interact with various sialoproteins or glycoproteins.32,33 Consistently, although ACE2 is used to adsorb SARS-CoV-2, tumor cell-derived microparticles (T-MPs) retain approximately 10% capacity to adsorb viral particles under ACE2-deficient conditions.16