In the present study, we witnessed the oncogenic nature of DLEU1 in breast cancer: higher level of DLEU1 was not only significantly associated with breast cancer (in contrast to normal breast tissues), but also with those of advanced TNM stages, positive lymph node metastasis, or TNBC subtype (in contrast to luminal or HER2-positive subtype). The gene discussed is ERBB2; the disease is breast carcinoma.