DLEU1 and breast cancer: Next, we measured the effects of knocking down DLEU1 on multiple malignant behaviors of cancer cells and found that when compared to control shRNA (shNC)-transfected cells, shDLEU1#2 or #3 cells significantly reduced short-term cell proliferation (Fig. 2B), long-term proliferation (Fig. 2C), migration (Fig. 2D), and invasion (Fig. 2E), suggesting that DLEU1 critically controls multiple malignant phenotypes of breast cancer cells.