Drug treatment-induced BRD9 degradation correlated with the drug sensitivity of the ALL cell lines: for example, partial BRD9 degradation was observed in less BRD9 degrader-sensitive NALM6 cells whereas BRD9 degradation was complete for more BRD9 degrader-sensitive lines such as RS4;11 and SEM (Fig. 4A, B, Supplementary Fig. 5A–E). The gene discussed is BRD9; the disease is acute lymphoblastic leukemia.