This phenotype may indicate a role for Adq-perivascular cells in the physiological remodeling of the transcortical vascular channels.30 In addition, it may shed some light on the cell type involved in the pathogenesis of Gsα-related skeletal diseases with abnormal bone resorption such as hyperparathyroidism and certain phases of lesion development in FD of bone. The gene discussed is GNAS; the disease is bone disorder.