CRLF2 and acute lymphoblastic leukemia: Also, the following changes are typically found in DS-ALL: (i) CRLF2 gene (essential lymphoid signalling receptor) overexpression [8], (ii) Janus Kinase 2 (JAK2) receptor mutations [8], (iii) somatic IKZF1 deletions [9], (iv) hyperdiploidy [8, 10, 11, 12], (v) acquired HMGN1 [13], (vi) DYRK1A [14], (vii) PAX5 deletions [9], (viii) ETV6-IGH rearrangements [15], and (ix) less ETV-RUNX1 gene fusion than in non-DS-ALL [5].