Lastly, in analyses examining the role of systemic inflammation and obesity-related diseases in the four robust obesity-symptom associations [UK Biobank], the results revealed that approximately-one third (23.5 % to 31.2 %) of these associations was attributable to elevated levels of CRP and a history of or current obesity-related morbidity (Table 2). This evidence concerns the gene CRP and obesity due to melanocortin 4 receptor deficiency.