After further adjustment for socio-demographic characteristics, chronic illnesses, and CRP, these associations were slightly weaker but remained statistically significant at conventional levels (obesity class I: 1.32; 95 %, 1.10 to 1.57: obesity class II-III:1.70; 95 %,1.34 to 2.14). This evidence concerns the gene CRP and obesity due to melanocortin 4 receptor deficiency.