Inflammatory markers such as interleukin-6 (IL-6) and CRP are synthesized by adipocytes (Tilg & Moschen, 2006), and higher levels of body fat, in particular visceral fat, are related to both metabolic inflammation and depression-related symptoms (Milaneschi et al., 2019, Speed et al., 2019). The gene discussed is CRP; the disease is major depressive disorder.