For example, in the context of familial forms of amyotrophic lateral sclerosis (ALS), mutations to superoxide dismutase 1 (SOD1) affect the stability of the SOD1 dimer and promote the formation of protein deposits that accumulate through interactions among unfolded or partially unfolded monomeric states (Gomez and Germain, 2019; Meiering, 2008). The gene discussed is SOD1; the disease is amyotrophic lateral sclerosis.