When KITENIN acts as an enhancer of invasion in CRC cells, it serves as a scaffolding protein to form the functional KITENIN complex in which the KITENIN homodimer offers benefits, such as structural hindrance to binding with RACK1 or to interaction of Nrdp1 with Myo10, which thereby protects the protein from degradation. The gene discussed is VANGL1; the disease is colorectal carcinoma.