The association of AF106564.1 with NTRK3 (ensembl ENSG00000140538) is also intriguing as NTRK genes code for tyrosine kinase receptors for growth factors in the CNS and activating fusions such as ETV6-NTRK3 or BTBD1-NTRK3 have oncogenic potential in some subsets of high-grade glioma (49). Here, BTBD1 is linked to malignant glioma.