With CXCL10, CXCL12, and CXCL13 being locally enriched, CXCR4 and CXCR5 can be expected to be more involved in the organization, while CXCR3 may be more related to the recruitment of B cells in the MS brain (8). This evidence concerns the gene CXCL12 and myeloid sarcoma.