CFHR3 and hepatocellular carcinoma: Furthermore, cell function assays showed that the promotional effects upon downregulation of CFHR3 induced by CFHR3 stable knockdown or miR-590-3p on HCC cell growth (Figure 5D), migration as well as invasion in vitro (Figure 5E–5G) as well as cell metastasis in vivo (Figure 5H–5L) were also attenuated by S3I-201.