We detected an increased communication probability of H2-k1-Cd8a, H2-k1-Cd8b1, H2-d1-Cd8a, and H2-d1-Cd8b1 pairs between PT subtypes and T lymphocyte subtypes the in AAN group, in agreement with the upregulation of MHC II antigen processing and presentation pathway (Figure 3G and Figure 5F). Here, CD8A is linked to Balkan nephropathy.