To evaluate the impact of tumor cell–intrinsic PRC2 inactivation on the TME in vivo, we generated a histologically confirmed Nf1–/– Cdkn2a/b–/– murine MPNST tumor–derived cell line (SKP605) from skin-derived precursors (SKPs) of C57BL/6J mice (45, 46) (Supplemental Figure 4, A and B). Here, NF1 is linked to malignant peripheral nerve sheath tumor.