SUZ12 and cancer: PRC2 loss in MPNSTs was confirmed by the loss of H3K27me3 immunostaining and/or genetic inactivation of EED or SUZ12 by MSK-IMPACT (MSK – integrated mutation profiling of actionable cancer targets) (30) (Supplemental Figure 1A and Supplemental Table 1; supplemental material available online with this article; https://doi.org/10.1172/JCI153437DS1).