Further, we observed a reduction of tumor immune infiltrates in PRC2-loss tumors across all major subclasses of immune cells, including MHCII+CD11c+ DCs, TCRβ+ T cells, B220+ B cells, and, to a lesser extent, F4/80hiCD11b+ macrophages (Figure 5F, Supplemental Figure 4G, and Supplemental Figure 5), phenocopying the cold TME of human PRC2-loss MPNSTs. This evidence concerns the gene ITGAX and neoplasm.