PTPRC and neoplasm: We noted some differences in tumor immune filtrates between the murine and human MPNSTs, e.g., B220+ tumor–infiltrating B cells that appeared more enriched in murine MPNSTs compared with human tumors (Figure 1, D and E, and Figure 5F), probably due to host differences between mice and humans, syngeneic transplant systems, a lack of full recapitulation of the entire genetic alteration landscape, and the differential timing of tumor development.