Most of the published studies have focused on the relation between single nucleotide polymorphisms (SNPs) in ERCC5 and the risk of various types of cancer [14–18] as well as cancer prognosis [19–21] while few studies have addressed the association between XPG polymorphisms and chemotherapy outcome [22, 23] and most of them were done on Asian populations. Here, ERCC5 is linked to cancer.