It is also worth noticing that the decrease in BACE1 protein levels by hypoxia was most pronounced in the cortex of 4-month-old APP/PSEN1 mice that did not show a significant reduction in amyloid plaque load, while BACE1 was not decreased in 10-month-old mice with the most robust reduction of brain amyloid plaque load. Here, BACE1 is linked to amyloidosis.