P2RX4 and amyotrophic lateral sclerosis: Finally, we report, using innovative double transgenic SOD1-G93A (SOD1) mice expressing non-internalized P2X4mCherryIN mice (namely P2X4KI) [48] or lacking the P2X4 gene (P2X4KO), that P2X4 contribute to ALS progression and survival in SOD1 mice.