The significantly higher efficacy of RHL-Fe3O4@PVA@p-CoA/GA treatment over vancomycin antibiotic control in VRSA was detected by downregulation of icaA and icaD genes (0.2 to 0.4; P < 0.05) (Fig. 9B). The gene discussed is DFFA; the disease is Vancomycin-Resistant Staphylococcus Aureus Infection.