Some JmjC KDMs are reported to be induced by pseudohypoxic stress, which activates HIF‐1α signaling in normoxia via oxidative stress, leading to alterations in mitochondrial metabolites, ceramide/sphingosine‐1‐phosphate, and the insulin/PI3K/mTOR, NF‐κB, JAK/STAT, and TGF‐β/Smad3 pathways,119 all of which are abnormal in AD.120, 121, 122, 123, 124, 125. The gene discussed is INS; the disease is Alzheimer disease.