There is a significant increase in PLOD1 in whole blood from AD fast progressors compared to slow progressors24 (fast progressors: early AD patients with changes in Clinical Dementia Rating‐Sum of Boxes [CDR‐SB] scores ≥2 points/year; slow‐progressors are those with CDR‐SB changes of <2 points/year24). This evidence concerns the gene PLOD1 and Alzheimer disease.