In the current study, we systematically mapped and compared the brain vasculomes from young and old wild‐type mice versus young and old transgenic mice expressing mutant amyloid precursor protein (APP) and presenilin 1 (PSEN1) (APPswe/PSEN1dE9) that mimic the vascular deposition of amyloid in AD and CAA (Garcia‐Alloza et al., 2006). Here, APP is linked to amyloidosis.