Alzheimer’s disease (AD) is characterized by two prominent histopathological features, namely, extracellular amyloid-β peptides (Aβ) deposition1 and presence of intraneuronal neurofibrillary tangles of aberrant hyperphosphorylated tau protein in neurons2, which lead to synaptic loss, neuronal loss, and memory impairment. The gene discussed is MAPT; the disease is memory impairment.