Multiple GWAS have found about 32 risk loci related to stroke and stroke subtypes (e.g., TSPAN2, PMF1‐SEMA4A, CASZI, WNT2B) and 18 associated pathways, including various cardiac pathways, muscle‐cell fate commitment, and nitric oxide metabolic process.[79] Despite these findings, there has been no reported gene therapy that targets these risk loci so far. Here, TSPAN2 is linked to Stroke.