MKNK2 and neoplasm: They first identified that the gene MKNK2 encoding the kinase Mnk2 could be alternatively spliced into two isoforms, namely MnK2a and Mnk2b, where the former isoform suppressed tumor growth whereas the latter isoform promoted the tumor progression.[270] Following these findings, they specifically designed an AON that induced a strong switch in the alternative splicing of MnK2, promoting the expression of MnK2a while suppressing the expression of MnK2b.