GBA1 and Cognitive impairment: [126] To date, more than 300 different mutations are reported in GBA, including point mutations, frameshift or in‐frame alterations, splice junction mutations, and recombination events with a highly homologous pseudogene downstream.[127, 128]GBA variants have been identified to be linked to cognitive impairment and motor symptoms in PD patients over time.[129, 130] However, the mechanisms underlying the GBA mutations and the pathology of PD remain disputative.