TREM2 and Alzheimer disease: A recent study by Wang et al. shows that systematic delivery of nanocomplexes carrying TREM2‐expressing plasmid to microglia significantly enhanced Aβ clearance and improved cognitive performance in AD mice.[105] Some other genetic factors, such as CD33, CD36, and toll‐like receptors‐4 (TLR4), have also been found to reduce Aβ‐induced cytokine production and regulate neuroinflammation.