They showed that the nanocomplex was able to create indels to disable the BACE‐1 gene in the disease mice as evidenced by significant reduction of APP in the mouse brain.[95] A less invasive approach was also explored by intravenous administration of CRISPR/Cas9‐loaded liposome‐templated hydrogel NPs, targeting polo‐like kinase 1 (PLK1), in both orthotopic and subcutaneous GBM mouse tumor models. This evidence concerns the gene BACE1 and glioblastoma.