As a transcription repressor, Kaiso controls the cell cycle through repressing CCND1 and CCNE1 expression, affects Notch signalling pathway in intestinal cells through targeting DLL1 and JAG1 promoter, and inhibits the proliferation and invasion of tumour cells through downregulating MMP7, MTA2 and other genes [9, 10, 11, 12]. Here, ZBTB33 is linked to neoplasm.